Biomarkers of LONG COVID (LONG COVID_LCM)

San Donato Group (GSD)

Status: Completed

Conditions: Long COVID

Treatments: Diagnostic Test: Measurement of ncRNAs and cytokines

Study type: Observational

Funder types: Other

Identifiers

NCT05672602

LONG COVID_LCM

Details and patient eligibility

About

This observational prospective study is aimed to investigate noncoding RNAs (ncRNAs) such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) as potential peripheral blood biomarkers of severity and poor prognosis in COVID-19 patients. Patients with intermittent or permanent symptoms after COVID-19 at the moment of the recruitment were considered affected by LONG COVID disease. In particular, the aim is to clarify if COVID-19 biomarkers remain deregulated similarly in LONG COVID patients. To this purpose, plasma and peripheral blood mononuclear cells (PBMCs) will be collected and patients will be compared to individuals who have never been affected by COVID-19 or asymptomatic LONG COVID patients.

Full description

The investigators will collect plasma and PBMCs from consenting subjects. The investigators will evaluate the expression of miRNAs, lncRNAs and cytokines in patients affected by LONG COVID admitted to IRCCS Policlinico San Donato during the acute phase of COVID-19. In particular, miRNAs will be evaluated in plasma samples while lncRNAs in PBMC samples to clarify their potential as biomarkers.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Previous COVID-19 infection

Exclusion criteria

Trial design

100 participants in 3 patient groups

LONG COVID patients

Description:

Measurement of ncRNAs and cytokines in patients with new diseases or intermittent or permanent symptoms after COVID-19 at the moment of the recruitment

Treatment:

Diagnostic Test: Measurement of ncRNAs and cytokines

Controls

Description:

Measurement of ncRNAs and cytokines in Individuals who have never suffered from COVID-19 at the moment of the recruitment

Treatment:

Diagnostic Test: Measurement of ncRNAs and cytokines

Asymptomatic LONG COVID patients

Description:

Measurement of ncRNAs and cytokines in patients who have never suffered from LONG COVID symptoms or with only resolved symptoms at the moment of the recruitment

Treatment:

Diagnostic Test: Measurement of ncRNAs and cytokines