Biomarkers, Risk Assessment, Imaging, and Neurodegeneration in Cerebral Small Vessel Disease (BRAIN-CSVD)

Zhejiang Hospital

Status: Not yet enrolling

Conditions: Cerebral Small Vessel Disease

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT07093515

BRAIN-CSVD

Details and patient eligibility

About

The BRAIN-CSVD study is a single-center prospective cohort study focusing on cerebral small vessel disease (CSVD).Patients enrolled in this research will undergo assessments for vascular risk factors, cognitive and other neurological functions, neuroimaging, and biomarkers. The study aims to explore imaging and biomarker predictors of CSVD progression, and the pathophysiological mechanisms of CSVD.

Full description

Cerebral small vessel disease (CSVD) is a common imaging finding in elderly population and can impair cognitive and other neurological functions. Radiologically, CSVD may manifest as white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces and so on. Due to its complex imaging presentations and diverse neurological impacts, current preventive and therapeutic options for CSVD remain limited. This study involves collecting vascular risk factors, assessing global cognitive function, gait, and other neurological functions, performing multimodal MRI scans, and collecting blood samples from CSVD patients. The goal is to identify imaging markers and biomarkers that predict disease progression and to investigate the underlying pathophysiological mechanisms.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >= 18 years old;
• Cerebral small vessel disease on MR imaging.

Exclusion criteria

• Cerebral infarction (except lacunar infarcts), cerebral hemorrhage, brain tumors, epilepsy, severe traumatic brain injury, or prior brain surgery;
• Secondary white matter hyperintensities due to inflammatory, toxic causes and so on;
• Contraindications to MRI.

Trial design

500 participants in 2 patient groups

Patients with cerebral small vessel disease

Description:

Patients with at least one following imaging finding: white matter hyperintensities (Fazekas \>or=1), lacune, cerebral microbleeds, recent small subcortical infarcts, or enlarged perivascular spaces (Grade 2 or more).

Treatment:

Other: No intervention

Patients without cerebral small vessel disease

Description:

Patients without any following imaging finding: white matter hyperintensities (Fazekas \>or=1), lacune, cerebral microbleeds, recent small subcortical infarcts, or enlarged perivascular spaces (Grade 2 or more).

Treatment:

Other: No intervention