Biomarkers to Measure Treatment Response for Alcohol Dependence

University of Maryland Baltimore (UMB)

Status: Completed

Conditions: Alcohol Dependence

Treatments: Other: Alcohol administration; Placebo administration

Study type: Interventional

Funder types: Other

Identifiers

NCT02315885

HP-00060091

Details and patient eligibility

About

The purpose of the research study of the K23 award is to develop a blood test that can check how much alcohol a person has consumed in the past few days. We will enroll heavy social drinkers who do not have alcohol-related problems but used to drinking 5 or more beers on a single occasion. Both men and women between ages 21 and 65 years can join the study. All participants must be of European decent.

Enrollment: 29 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Experienced binge drinking episode(s) (5 or more standard drinks for men and 4 or more standard drinks for women consumed in about 2 hours according to NIAAA definition) in the past 30 days

Exclusion criteria

• DSM-IV diagnosed alcohol dependence, other drug dependencies including nicotine dependence

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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29 participants in 3 patient groups, including a placebo group

placebo alcohol

Placebo Comparator group

Description:

\<0.05% alcohol

Treatment:

Other: Alcohol administration; Placebo administration

alcohol middle dose

Active Comparator group

Description:

alcohol dose=0.45g/kg for women and 0.5g/kg for men

Treatment:

Other: Alcohol administration; Placebo administration

alcohol high dose

Active Comparator group

Description:

alcohol dose=0.90g/kg for women and 1.0g/kg for men

Treatment:

Other: Alcohol administration; Placebo administration