Biomechanics of Optic Neuropathy

University of Miami

Status: Terminated

Conditions: Optic Neuropathy

Treatments: Device: Optical Coherence Tomography (OCT); Device: magnetic resonance image (MRI)

Study type: Observational

Funder types: Other

Identifiers

NCT02982499

20160376

Details and patient eligibility

About

The participant is being asked to be a subject in this research study because the participant may have a disorder that can cause optic nerve damage and impairment of his/her visual function which is called optic neuropathies (ON). Optic neuropathy refers to damage to the optic nerve (a "cable" connecting the eyes and the brain to transmit the visual signals) due to any cause.In this study, the investigator is using magnetic resonance imaging (MRI) and ophthalmic measures such as optic coherent tomography(OCT), which are non-invasive imaging tests to measure the changes in eye globe shape ,the flow of blood and brain fluid. It is hoped that this study will provide new knowledge that may allow the investigator to better understand the cause of symptoms associated with optic neuropathy and ways to better monitor what is happening.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria :

• 18 years old and on
• Patients with optic neuropathy(10) and age controlled healthy subjects(10)

Exclusion Criteria :

• For patients: Subjects with history of neurological or ocular disease other than optic neuropathy and refractory error.
• For healthy control group: History of systemic disease except hypertension.
• Pregnant women and prisoners will be excluded.

Trial design

10 participants in 2 patient groups

control group

Description:

Healthy participants will receive a one-time assessment of quantitative Magnetic Resonance Imaging (MRI) and spectrum domain optical coherence tomography (OCT).

Treatment:

Device: magnetic resonance image (MRI)

Device: Optical Coherence Tomography (OCT)

optic neuropathy group

Description:

Participants with optic neuropathy will receive a one-time assessment of quantitative Magnetic Resonance Imaging (MRI) and spectrum domain optical coherence tomography (OCT).

Treatment:

Device: magnetic resonance image (MRI)

Device: Optical Coherence Tomography (OCT)