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Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma

T

Tianjin Medical University Eye Hospital

Status

Completed

Conditions

Subluxation of Lens

Study type

Observational

Funder types

Other

Identifiers

NCT03752710
Tianjin LS study

Details and patient eligibility

About

In this work, we evaluated the biometry data of lens subluxation inducing acute angle closure which were misdiagnosed as primary angle closure at the first visit, and compared with the data of chronic angle closure glaucoma, cataract, primary acute angle closure.

Enrollment

183 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

ASAC-LS was diagnosed according to the following criteria, including sudden pain in the eye, decreased vision with or without nausea and vomiting. Slit lamp microscopy reveals phacodonesis, lens inclination or vitreous herniation into the anterior chamber, central and peripheral shallow anterior chamber, and asymmetric iris bulge. All patients were confirmed during the surgery to have LS.

APACG was diagnosed with the following criteria6, 7 8, including substantially elevated IOP and closed angle, acute eye pain, blurred vision, or nausea and vomiting. More importantly, ischemic injury caused by acute ocular hypertension, ciliary or mixed congestion, corneal edema, and glaucoma flecks should be detected.

The diagnostic criteria of CPACG included narrow angle with anterior synechiae of varying widths, IOP > 22 mmHg, and glaucomatous optic disc damage and visual field shrinkage9-11 The angle closure should be more than two quadrants, yet there was no ischemic injury in the anterior segment caused by acute ocular hypertension.

Exclusion criteria were history of laser peripheral iridotomy or peripheral iridectomy, glaucoma filtration surgery, angle closure caused by ocular trauma, uveitis, neovascularization or lens swelling or hyper mature lens. The patients with acute angle closure in both eyes were excluded. The subjects in which Lenstar LS900 examination could not be performed because of severe lens opacity or corneal edema were also not included in the study.

Trial design

183 participants in 4 patient groups

Acute primary angle closure
Acute secondary angle closure induced by LS
Cataract
Primary chronic angle closed glaucoma

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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