Biomimetic Hydroxyapatite Toothpaste and Mouthwash for Reducing Dental Sensitivity (SENS-BIOREP)

University of Pavia

Status: Completed

Conditions: Gingival Recession Localized Moderate; Tooth Sensitivity; Gingival Recession Generalized Moderate

Treatments: Device: Biorepair Total Protection Toothpaste; Device: Biorepair High-Density Mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT07057141

2025-SENSBIOREPAIR

Details and patient eligibility

About

This randomized controlled clinical trial evaluates the effectiveness of a biomimetic hydroxyapatite-based toothpaste and mouthwash in reducing dental sensitivity in patients with gingival recession. A total of 100 participants will be randomly assigned to two groups. The control group will receive Biorepair Total Protection toothpaste, and the trial group will receive Biorepair high-density mouthwash. Both products will be applied for 30 seconds. Dental sensitivity will be assessed before and after treatment using the Shiff Air Index and the Visual Analogue Scale (VAS).

Enrollment: 100 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female subjects aged between 18 and 70;
• Subjects with gingival recession and tooth sensitivity;
• Subjects who have agreed to give their free written informed consent to participate in the study.

Exclusion criteria

• Male and female subjects who are not adults;
• Subjects without gingival recessions;
• Subjects without dental sensitivity;
• Subjects with poor participation or insufficient motivation to participate in this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Control Group - Toothpaste

Active Comparator group

Description:

50 participants will receive a single 30-second application of Biorepair Total Protection toothpaste. The intervention aims to reduce dental sensitivity in patients with gingival recession. Clinical indices (Schiff Air Index and VAS) will be assessed before and after application.

Treatment:

Device: Biorepair Total Protection Toothpaste

Trial Group - Mouthwash

Experimental group

Description:

50 participants will receive a single 30-second application of Biorepair high-density mouthwash. The intervention aims to reduce dental sensitivity in patients with gingival recession. Clinical indices (Schiff Air Index and VAS) will be assessed before and after application.

Treatment:

Device: Biorepair High-Density Mouthwash