Bionenergetic Balance During CVVH (BALANCE)

Universitair Ziekenhuis Brussel

Status: Active, not recruiting

Conditions: Resting Energy Expenditure; Energy Metabolism; Acute Kidney Injury; Nutrition Therapy; Continuous Venovenous Hemofiltration

Treatments: Other: bioenergetic balance

Study type: Observational

Funder types: Other

Identifiers

NCT06483542

BUN 1432022000231

Details and patient eligibility

About

The bioenergetic balance is the sum of energy exchanged during CRRT and is mostly defined by citrate glucose and lactate. When CRRT was performed with the older dialysis fluids, glucose and lactate could be an important source of energy next to citrate when used as predilution (6, 7). During continuous venovenous hemofiltration (CVVH), a subgroup of CRRT which is performed with the newer dialysis fluids without lactate or glucose as advocated by the KDIGOguidelines, glucose and in a minor way lactate mostly induce a loss of energy. The first aim is to determine how this bioenergetic balance impacts energy need compared to the measured energy with indirect calorimetry and how nutrition therapy needs to be adapted.

Also, disease specific predicting equation have been created for patients suffering from acute kidney injury treated with renal replacement therapy. How this predicting equation and other existing predicting equations agree with the measured REE has not been validated yet. The second aim is to determine how predictive equations correlate with measured REE in patients treated with CVVH.

Enrollment: 50 patients

Sex: All

Ages: 18 to 130 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted to the adult ICU (01/01/2021-30/09/2022)
• At least one indirect calorimetry measurement (ventilator) or calculation based on harris benedict OR 25Kcal/kg/day
• Combined with bio energetic balance measurement
• Receiving CVVH during intensive care stay

Exclusion criteria

• Patients admitted outside of the inclusion period will be excluded
• The absence of an indirect calorimetry measurement (ventilator) or calculation - based on the Harris Benedict OR 25Kcal/kg/day formula OR The absence of a bio energetic balance measurement
• The absence of CVVH during intensive care stay
• Pediatric (intensive care unit) patients

Trial design

50 participants in 1 patient group

Group 1

Description:

all patients

Treatment:

Other: bioenergetic balance