Biopsy of Human Tumors for Cancer Stem Cell Characterization: a Feasibility Study

Stanford University

Status: Completed

Conditions: Head and Neck Cancers; Head and Neck Cancer

Treatments: Procedure: tumor biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT00610415

SU-12142007-934 (Other Identifier)

ENT0023

98543 (Other Identifier)

NCT00610415

10514

Details and patient eligibility

About

To see if a limited sampling of tumor tissue from human subjects is a feasible way to gather adequate tissue for cancer stem cell quantification.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:1. Patients with malignant tumors seen at the Stanford University Cancer Center. Eligible patients will have a diagnosis of squamous cell carcinoma (HNSCC) and will have been seen in the Stanford Head and Neck Oncology Program. A decision to undergo surgery at Stanford will have been made, prior to recruiting patients for the study, and prior to obtaining the samples during surgery. (Histological confirmation of the diagnosis need not be made prior to obtaining consent.) 2. A definitive resection of a malignant tumor is planned. 3. Surgeon judgment that the definitive procedure will not be compromised by including

• FNA
• Core needle biopsy
• Cup forceps or punch biopsy of<4mm. 4. Informed consent documented prior to procedure