Bisphenol Role in the Pathogenesis of PCOS

Aljazeera Hospital

Status

Completed

Conditions

PCOS

Treatments

Diagnostic Test: Measurement of Bisphenol in urine

Study type

Observational

Funder types

Other

Identifiers

NCT03436108

Bisphenol and PCOS

Details and patient eligibility

About

Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria .

Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..

Full description

Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites .

Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid .

Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .

Enrollment

220 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age group: 18-40
Females
Diagnosed a case of polycystic ovary syndrome

Exclusion criteria

• Female patients with other acute or chronic illness
- Cardiovascular disease
- Neoplasms
- Current smoking, diabetes mellitus,
- Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood pressure 140/85 mm Hg).