Blackberry Polyphenol Intake and Fuel Management

Beltsville Human Nutrition Research Center (BHNRC)

Status

Completed

Conditions

Fuel Management

Treatments

Other: Jello

Other: Blackberry

Study type

Interventional

Funder types

Other U.S. Federal agency

Identifiers

NCT01932879

HS44

Details and patient eligibility

About

Studies in animals have suggested that berry preparations or anthocyanin-rich berry extracts can reduce body fatness. Previous studies with tea catechins, which belong to the flavonoid class of chemicals as do anthocyanins, suggest that these compounds can alter fat oxidation, and this may be the mechanism by which body fatness is influenced by anthocyanin intake. Well-controlled studies in humans are lacking.

Enrollment

35 patients

Sex

Male

Ages

25 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Exclusion Criteria:

Younger than 25 years old or older than 75 years old
Female
Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol (dicumarol), or Miradon (anisinidione)
Presence of any gastrointestinal disease, metabolic disease, or malabsorption syndromes that may interfere with the study goals
Have been pregnant during the previous 12 months, are currently pregnant or lactating, or plan to become pregnant during the study
Type 2 diabetes requiring the use of oral antidiabetic agents or insulin
Fasting triglycerides greater than 300 mg/dL
Fasting glucose greater than 126 mg/dL
History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets)
Use of prescription or over-the-counter antiobesity medications or supplements (e.g., phenylpropanalamine, ephedrine, caffeine) during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity
Active cardiovascular disease (such as a heart attack or procedure within the past three months or participation in a cardiac rehabilitation program within the last three months, stroke, or history/treatment for transient ischemic attacks in the past three months, or documented history of pulmonary embolus in the past six months).
Use of any tobacco products in past 3 months
Use of oral or IV antibiotics during the month preceding the study
Unwillingness to abstain from herbal supplements for two weeks prior to the study and during the study
Known (self-reported) allergy or adverse reaction to blackberries
Unable or unwilling to give informed consent or communicate with study staff
Self-report of alcohol or substance abuse within the past twelve months and/or current acute treatment or rehabilitation program for these problems (Long-term participation in Alcoholics Anonymous is not an exclusion)
Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol