Blister Packaging Medication to Increase Treatment Adherence and Clinical Response (BP)

VA Eastern Colorado Health Care System

Status: Completed

Conditions: Suicide, Attempted; Medication Adherence; Deliberate Overdose; Accidental Overdose

Treatments: Other: Dispense as usual; Other: Blister packaging medications

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01118208

W81XWH-09-1-0723

Details and patient eligibility

About

This quantitative, interview-based study will determine if increased prescription medication adherence via blister pack administration will reduce suicide related behavior among the high risk population of patients discharged from a psychiatric inpatient unit. The aims of the project are to determine whether blister packaging medication significantly increases treatment adherence and if blister packaging significantly decreases intentional self-poisoning behavior (i.e., suicide attempts and completions). By tracking former psychiatric inpatients for 12 months post-discharge and obtaining monthly medication adherence ratings, we will determine if blister packaging (BP) medications leads to better adherence than dispensing as usual (DUA). The psychiatric patients we will be recruiting have been diagnosed with, major affective disorder, bipolar affective disorder, post-traumatic stress disorder, or schizophrenia (or any combination of these diagnoses). By tracking former psychiatric patients for 12 months post-discharge and obtaining monthly reports (self-report and medical record review) of suicide-related behaviors, we will determine if patients in the BP condition have less intentional self-poisoning behavior than those in the DAU condition.

Enrollment: 303 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18 or older
• diagnosed with major affective disorder,
• bipolar affective disorder,
• post-traumatic stress disorder, or
• schizophrenia (or any combination of these diagnoses)
• under voluntary status at some point during admission
• currently prescribed medications
• deemed capable of managing their own medications after discharge
• not currently active duty in any branch of the military
• able to correctly answer questions verifying they understand the consent form
• English-Speaking

Exclusion criteria

• Under the age of 18
• Not under voluntary status at some point during admission
• Not currently prescribed medications
• Not able to manage their own medications after discharge
• Non-English-speaking
• Currently active duty in any branch of the military
• Inability to correctly answer questions indicating comprehension of information on the consent form

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

303 participants in 2 patient groups

Blister Packaging

Experimental group

Description:

Patients will receive all prescription medications on blister pack cards.

Treatment:

Other: Blister packaging medications

Dispense as Usual

Active Comparator group

Description:

Patients will receive all prescription medications in standard pill bottles.

Treatment:

Other: Dispense as usual