Blockade of Vascular Potassium Channels During Human Endotoxemia

Radboud University Medical Center

Status and phase: Completed; Phase 1

Conditions: Endotoxemia

Treatments: Drug: Potassium channel blockers: TEA, Quinin, Tolbutamide; Drug: endotoxin; Drug: L-NMMA

Study type: Interventional

Funder types: Other

Identifiers

NCT00185003

PP02

ZONMW grant 907-00-056

Details and patient eligibility

About

Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.

Enrollment: 36 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers

Exclusion criteria

• drug, alcohol, nicotine abuse

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)