Blood and Tumor Tissue Samples From Young Patients With Acute Myeloid Leukemia

Children's Oncology Group

Status

Completed

Conditions

Leukemia

Treatments

Other: laboratory biomarker analysis

Other: flow cytometry

Genetic: gene expression analysis

Genetic: western blotting

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01139333

CDR0000671452 (Other Identifier)

NCI-2011-02222 (Registry Identifier)

AAML10B4

COG-AAML10B4 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.

Full description

OBJECTIVES:

To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML).
To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients.

OUTLINE: This is a multicenter study.

Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.

Enrollment

52 estimated patients

Sex

All

Ages

Under 17 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: