Blood Biomarkers in Pediatric Kidney Transplant Recipients (Omnigraf)

University of Minnesota (UMN)

Status: Active, not recruiting

Conditions: Rejection of Kidney Allograft

Treatments: Other: Observational group

Study type: Observational

Funder types: Other

Identifiers

NCT05477082

PEDS-2022-30750

Details and patient eligibility

About

The objective of the proposed study is to assess whether a blood biomarker can be used to monitor the response to rejection treatment in pediatric kidney transplant recipients with biopsy-proven acute cellular or antibody mediated rejection. The study hypothesizes that blood gene expression profile and donor-derived cell-free DNA biomarkers (omnigraf) can be used to predict acute rejection and monitor its response to treatment.

Enrollment: 27 patients

Sex: All

Ages: Under 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Kidney transplant recipients
• Participants undergoing a for-cause kidney biopsy to rule out graft rejection
• Ages 21 years and less

Exclusion criteria

• Participants who have opted out of research
• Patients, less than 18 years of age, whose parents or legal guardians are illiterate and cannot read.
• Participants, 18 years and older, who are illiterate and cannot read.
• Participants, less than 18 years of age, whose parents or legal guardians do not speak English.
• Participants, 18 years and older, who do not speak English
• Participants who are pregnant as confirmed by medical records