Blood Cell RNA-Based Cancer Detection (eRBCDet)

Huazhong University of Science and Technology

Status: Enrolling

Conditions: Neoplasms; Cancer

Treatments: Diagnostic Test: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT05839834

blood-cell-RNA

Details and patient eligibility

About

Early diagnosis of cancer may provide patients with more treatment options and hopefully prolong survival. The purpose of this multi-center study is to collect peripheral blood from newly diagnosed cancer patients and healthy donors to establish a blood cell RNA-based model for the differentiation of cancer patients and healthy donors. The area under the receiver operating characteristic (AUROC), sensitivity and specificity of the test in the early detection of multiple cancers will be measured.

Enrollment: 5,000 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for All the Participants

1. Age 18 years or older
2. Provide informed consent

Exclusion Criteria for All the Participants:

1. Pregnancy or lactating women
2. Received a blood transfusion within 1 month
3. Received anti-cancer treatment within 3 years
4. Known prior diagnosis of cancer
5. Poor health status or unfit to tolerate blood draw

Trial design

5,000 participants in 2 patient groups

Cancer

Description:

Patients with new diagnosis of cancers

Treatment:

Diagnostic Test: Blood test

Non-cancer

Description:

Healthy participants

Treatment:

Diagnostic Test: Blood test