Blood Collection From Individuals With Lung Disease for Genetic Studies

Weill Cornell Medicine (WCM)

Status: Completed

Conditions: Asthma; Lung Cancer; Cystic Fibrosis; COPD; Interstitial Lung Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00362739

0508008095

Details and patient eligibility

About

This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, cystic fibrosis, and lung cancer.

Full description

The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.

Enrollment: 3,087 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must provide informed consent

• Males and females, age 18 years and older

• Lung disease proven by at least one of the following:

  • symptoms consistent with pulmonary disease
  • chest X-rays consistent with lung disease
  • pulmonary function tests consistent with lung disease
  • lung biopsy consistent with lung disease
  • family history of lung disease
  • disease of organs with know associated with lung disease
  • individuals suspected of history of lung disease based on history and/or physical examination
  • normal controls (individuals without history of lung disease) to be sampled to provide a comparison to the lung disease cohort.

Exclusion criteria

• Drug and/or alcohol abuse within the past six months
• Females who are pregnant or nursing

Trial design

3,087 participants in 2 patient groups

1: Lung Disease

Description:

Individuals with at least one of the following: (1)symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination

2: Normal Controls

Description:

Individuals without a history of lung disease