Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia (APHERESE)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Preeclampsia

Treatments: Biological: A collection of maternal plasma and serum

Study type: Observational

Funder types: Other

Identifiers

NCT03188900

SC3455

Details and patient eligibility

About

The aim of the study is to setup a collection of maternal plasma and serum from patients with preeclampsia and normal pregnancy for in vitro validation of new therapeutics based on extra-corporal removal of sFlt-1

Full description

A collection of maternal plasma and serum from patients with preeclampsia (PE) and normal pregnancy (NP) :

• Between 20WG and 23WG+6D : 20 patients with PE and 30 patients with NP
• Between 24WG and 27WG+6D : 20 patients with PE and 30 patients with NP
• Between 28WG and 31WG+6D : 20 patients with PE and 30 patients with NP
• Between 32WG and 35WG+6D : 20 patients with PE and 30 patients with NP
• Between 36WG and 40WG+6D : 20 patients with PE and 30 patients with NP

Enrollment: 236 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 50 years old
• Singleton pregnancies between 20 and 41 weeks of gestation
• Preeclampsia
• Normal pregnancy

Exclusion criteria

• Age<18
• Infectious disease: HIV, HBV or HCV
• Multiple pregnancies
• Opposition of the patient

Trial design

236 participants in 2 patient groups

preeclampsia

Description:

pregnancy with preeclampsia

Treatment:

Biological: A collection of maternal plasma and serum

control

Description:

pregnancy without preeclampsia

Treatment:

Biological: A collection of maternal plasma and serum