ClinicalTrials.Veeva

Menu

Blood Donation Could Improve Insulin Sensitivity (GLUCFER)

U

University of Castilla-La Mancha

Status

Completed

Conditions

Ferritin
Blood Donation
Insulin Sensitivity

Treatments

Procedure: Whole blood standard donation

Study type

Interventional

Funder types

Other

Identifiers

NCT05791968
CEIC-CHUT-969

Details and patient eligibility

About

Studies in the literature suggest that people with obesity have an excess of stored iron. There is possibly an inverse relationship between ferritin levels and the actions of insulin on glycemic control. The reduction of stored iron by simply donating blood could result in improvements in glycemic control in people with obesity and prediabetes. We propose, to reduce ferritin levels through a standard donation of a unit of whole blood, and to measure if it positively affects glycemic control.

Full description

Individuals with pre-diabetes and abdominal obesity will be randomized to either a donation group (DON) or a control group (CONT) in a double-blind fashion (RCT).

Insulin sensitivity during an oral glucose tolerance test (OGTT) and isotopically measured rate of appearance of endogenous and exogenous glucose will be measured on 2 occasions.

  1. Two weeks prior to DON/CONT
  2. Two weeks after to DON/CONT

Indexes of the bodily iron stores will be measured after DON/CONT to evaluate if the primary treatment was effective.

Enrollment

89 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • have not donated in the last 3 months
  • IMC>25
  • fasting blood glucose 100-125 mg/dL
  • glycosylated hemoglobin levels between 5.7-6.4%

Exclusion criteria

  • to not meet donor bank requirements
  • insulin treatment for diabetes
  • anemia
  • hereditary hemochromatosis
  • heart disease
  • familial hypertriglyceridemia or hypobetalipoproteinemia
  • any disease that requires medication that interferes with iron or glucose metabolism

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

89 participants in 2 patient groups

DONATION GROUP
Active Comparator group
Description:
Participants will be measured before and after a standard blood bank donation (450 mL of whole blood withdrawal)
Treatment:
Procedure: Whole blood standard donation
CONTROL GROUP
Sham Comparator group
Description:
Participants will be measured before and after a sham blood donation (0 mL of whole blood withdrawal)
Treatment:
Procedure: Whole blood standard donation

Trial contacts and locations

1

Loading...

Central trial contact

Ricardo Mora-Rodriguez, PhD; Diego Mora-González, RN

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems