Blood Flow Analysis of the Human Mucosa After Vestibuloplasty Procedures

Semmelweis University

Status: Completed

Conditions: Mucogingival Defect

Treatments: Device: quantitative determination of VEGF; Device: laser speckle contrast imaging of the oral mucosa; Device: wound fluid measurement

Study type: Observational

Funder types: Other

Identifiers

NCT02975024

3/2013

Details and patient eligibility

About

Apply the LSCI for follow-up the postoperative microcirculation after surgical procedures to enlarge keratinized gingiva in order to characterize the kinetics of the blood flow changes during wound healing in human subjects.

Full description

Vestibuloplasty is the common name of those procedures designed to widen the zone of attached gingiva. The apically repositioned split thickness flap with a xenogeneic collagen matrix or with a combination of strip gingival graft and a xenogeneic collagen matrix are frequently used surgical techniques, however no data are available, how these graft tissues affect the microcirculation of the healing gingiva.

LSCI is a non-invasive, two dimensional method to evaluate microcirculation of different tissues. This new method let us monitor the entire surgical area real-time during the healing period.

The aim of the present study is to define blood flow patterns, which might characterize the wound healing of such surgical procedures during the first 6 months of healing in order to facilitate treatment.

Enrollment: 8 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Ages Eligible for Study: 18 Years to 45 Years Genders Eligible for Study: Both Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• clinical diagnosis of inadequate width of keratinized gingiva at the mandibular front region

Exclusion Criteria:

• pregnancy
• heavy smoking
• general diseases
• taking medications or having treatments which have an effect on mucosal healing in general (e.g. steroids, anti-inflammatory drugs)
• taking any other medications in the last three months (except contraceptives)

Trial design

8 participants in 2 patient groups

Mucograft

Description:

Laser speckle contrast imaging of the oral mucosa and wound fluid measurement and quantitative determination of VEGF after mandibular vestibuloplasty. Individuals of this pre-defined group are candidates of vestibuloplasty, where the keratinized gingiva will be enlarged by a combination of apically repositioned split thickness flap with a xenogeneic collagen matrix (Mucograft).

Treatment:

Device: wound fluid measurement

Device: laser speckle contrast imaging of the oral mucosa

Device: quantitative determination of VEGF

strip gingival graft + Mucograft

Description:

Laser speckle contrast imaging of the oral mucosa and wound fluid measurement and quantitative determination of VEGF after mandibular vestibuloplasty. Individuals of this pre-defined group are candidates of vestibuloplasty, where the keratinized gingiva will be enlarged by a combination of apically repositioned split thickness flap with a strip gingival graft and a xenogeneic collagen matrix (Mucograft). The strip gingival graft is harvested from the patient's palate.

Treatment:

Device: wound fluid measurement

Device: laser speckle contrast imaging of the oral mucosa

Device: quantitative determination of VEGF