Blood Gas and Bleeding Disorders in Healthy Volunteers Exposed to Nitroglycerin and Nitrogen Compounds

Emiliano Petrucci

Status: Completed

Conditions: Disorder of Blood Gas; Bleeding Disorder

Treatments: Diagnostic Test: Arterial blood gas analyses and haemostasis measures

Study type: Observational

Funder types: Other

Identifiers

NCT04201860

20/2016

Details and patient eligibility

About

The aim of the study was to investigate the possible relationship about blood gas and bleeding disorders in healthy volunteers of blasters and no blasters groups of the Italian National Mountain and Cave Rescue who handled nitrogen compounds and nitroglycerine and then they were exposed to combustion products from an accidental uncontrolled detonation of micro-charges during a cave unblocking procedure.

Full description

This was a field report of clinical data collected during an accidental uncontrolled detonation of micro-charges, while the cave unblocking procedure was performed by volunteers of blaster group and non blasters group of the Italian National Mountain and Cave Rescue, in a cave in Trieste (Italy; altitude entrance: 348 meters above sea level; total length: 413,5 meters; total depth of 307 meters).

Before going into the cave (Time 0), the following clinical data were collected: age, sex, body mass index; smoke (yes/no), heart rate, arterial blood pressure (mean arterial pressure), oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures.

After the accidental uncontrolled detonation of micro-charges, (Time 1) heart rate, arterial blood pressure, oxygen saturation measured with pulse oxymetry, epitympanic temperature, blood gases analyses and the haemostasis measures were recorded in each volunteers.

Enrollment: 94 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers of Italian National Mountain and Cave Rescue

Exclusion criteria

• gas exchange disorders
• quantitative abnormalities of coagulation assessment
• qualitative abnormalities of coagulation assessment

Trial design

94 participants in 2 patient groups

Blasters group

Description:

The volunteers of the blasters group of Italian Mountain and Cave Rescue handled explosive with nitrogen compounds and nitroglycerin of micro-charges, before the accidental uncontrolled detonation.

Treatment:

Diagnostic Test: Arterial blood gas analyses and haemostasis measures

Not blasters group

Description:

The volunteers of the blasters group of Italian Mountain and Cave Rescue did not handle explosive with nitrogen compounds and nitroglycerin of micro-charges, before the accidental uncontrolled detonation.

Treatment:

Diagnostic Test: Arterial blood gas analyses and haemostasis measures