Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Glycemic Control; Type 2 Diabetes

Treatments: Dietary Supplement: Sucrose consumption; Dietary Supplement: water consumption

Study type: Interventional

Funder types: Other

Identifiers

NCT00821665

07-3-004

Details and patient eligibility

About

Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes.

The objective of the study was to assess glycemic control in type 2 diabetes patients and healthy lean and obese controls under strict dietary standardization but otherwise free living conditions, with and without the consumption of soft drinks.

Enrollment: 39 patients

Sex: Male

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Lean NGT Group

• Normoglycemic (according to 2006 ADA guidelines)
• BMI < 27 kg/m2

Obese NGT Group

• Normoglycemic
• BMI 30- 35 kg/m2

Obese type 2 diabetes Group

• BMI 30- 35 kg/m2
• Oral blood glucose lowering medication

Exclusion criteria

• Exogenous insulin use
• Cardiac disease (any cardiac event in the last 5 years)
• HbA1c >10%
• Microalbuminuria: albumin:creatinine ratio >2,5

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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39 participants in 2 patient groups, including a placebo group

Sucrose

Experimental group

Description:

Sucrose

Treatment:

Dietary Supplement: Sucrose consumption

Water

Placebo Comparator group

Description:

Water

Treatment:

Dietary Supplement: water consumption