Blood Loss and Preeclampsia

University of Zurich (UZH)

Status: Enrolling

Conditions: Coagulation Disorder; Blood Loss; Pre-Eclampsia; Complicating Pregnancy

Treatments: Other: Blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT04777097

2020-00123

Details and patient eligibility

About

Study of blood loss in preeclamptic patients using mathematical formulae

Full description

Pre-eclampsia is a symptom complex that occurs in 2-5% of all pregnancies and leads to significant morbidity and mortality. It is associated with a risk of impaired coagulation caused by a reduced platelet count, very rarely by disseminated intravascular coagulation disorders. The degree of clotting correlates with the severity of preeclampsia. It is planned to calculate the blood loss using mathematical formulas and to compare the different blood loss in the two groups (preeclampsia vs. healthy pregnant women). Furthermore, this project will try to correlate the blood loss with the underlying coagulation situation. The aim is to be able to better assess the bleeding risk in healthy pregnant women, but also in pre-eclamptic patients in the future.

Enrollment: 120 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective or urgent caesarean section
• Written informed consent

Exclusion criteria

• Emergency caesarean section
• Familial coagulation disorder
• Hematological disorders that affect the platelet count, e.g. myelodysplastic syndrome (MDS)
• Taking anticoagulants
• Taking aspirin in the last 14 days
• Use of NSARs in the last 24 hours

Trial design

120 participants in 2 patient groups

healthy pregnant women

Description:

Healthy patients who receive a cesarean operation

Treatment:

Other: Blood sample

Pre-eclampsia

Description:

Patients with pre-eclampsia who receive a caesarean operation

Treatment:

Other: Blood sample