Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation

University of Sao Paulo

Status: Unknown

Conditions: Sports Nutritional Physiological Phenomena

Treatments: Dietary Supplement: Sodium bicarbonate; Dietary Supplement: Maltodextrin

Study type: Interventional

Funder types: Other

Identifiers

NCT03505970

SB_BloodMuscle

Details and patient eligibility

About

The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Enrollment: 15 estimated patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males

Exclusion criteria

• Smokers
• Chronic disease
• Prior or current use of steroids
• Use of creatine in the last 6 months
• Use of beta-alanine in the last 6 months

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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15 participants in 2 patient groups, including a placebo group

Sodium bicarbonate

Experimental group

Description:

0.3 g∙kg-1body mass of sodium bicarbonate

Treatment:

Dietary Supplement: Sodium bicarbonate

Placebo

Placebo Comparator group

Description:

Individuals will ingest 0.3 g/kg maltodextrin before undergoing exercise

Treatment:

Dietary Supplement: Maltodextrin