Blood Nitrate/Nitrite Concentrations Following Acute Ingestion of Resync in Men and Women

University of Memphis

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Resync + Collagen; Dietary Supplement: Resync; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT04125940

PRO-FY2020-67

Details and patient eligibility

About

This study evaluates acute ingestion of the dietary supplement Resync on blood nitrate/nitrite concentrations in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.

Full description

The product known as Resync contains a blend of nitrate-rich foods including beetroot, red spinach, turmeric, ginger root, and aronia berry extracts. Resync is sold commercially and marketed as an ergogenic aid and/or exercise recovery aid. Manufacturers of Resync recommend users take this product 60-90 minutes before an athletic event or 30-90 minutes after exercise. Resync bases these claims on prior studies investigating the individual ingredients' abilities to increase blood nitrate/nitrite levels; however, there are no clinical trials on the finished product itself.

The purpose of this pilot study is to determine the impact of acute, single ingestion of Resync products on blood nitrate/nitrite concentration in a sample of men and women. This will be a crossover trial in which participants take all 4 conditions: 1) 7.5g Resync, 2) 15g Resync, 3) 20g Resync+collagen, 4) placebo.

Enrollment: 20 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 18 - 29.9 kg/m2
• Non-smoker
• Non-vegan
• Not using nitrate-based dietary supplements

Exclusion criteria

• Diagnosed history of diabetes
• Diagnosed history of cardiovascular disease
• Diagnosed history of neurological disease
• Pregnant females

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 4 patient groups, including a placebo group

Placebo-controlled Arm

Placebo Comparator group

Description:

Placebo - 12oz water with food coloring

Treatment:

Other: Placebo

1 serving Resync Arm

Active Comparator group

Description:

12oz water + 7.5g Resync

Treatment:

Dietary Supplement: Resync

2 servings Resync Arm

Active Comparator group

Description:

12oz water + 15g Resync

Treatment:

Dietary Supplement: Resync

1 servings Resync+Collagen Arm

Active Comparator group

Description:

12oz water + 17g collagen + 2g Resync + 1g Carbohydrates

Treatment:

Dietary Supplement: Resync + Collagen