Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction (AORTA)

Zealand University Hospital

Status: Unknown

Conditions: Children; Obesity; Adolescent; Subclinical Organ Damage; Central Blood Pressure

Treatments: Behavioral: Lifestyle intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01310088

AORTA-SJ-166

Details and patient eligibility

About

The global epidemic of obesity in childhood continues to evolve and threaten future health and life expectancy primarily due to the increased incidence of cardiovascular disease. Obesity is strongly related to high blood pressure (hypertension) and both conditions pose a risk for target organ damage, which can follow a subject from childhood into adult life. The AORTA study will investigate central hemodynamics and organ damage in 100 obese children and adolescents in order to gain insight to the complex interplay of hypertension, obesity and subclinical damage in order to intensify more precise prevention, thereby reducing the future development of cardiovascular disease.

Enrollment: 100 estimated patients

Sex: All

Ages: 10 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 10-18
• BMI for age and sex above 95 percentile
• referred for treatment at the The Children's Obesity Clinic, Department of Paediatrics, Holbaek Hospital, University of Copenhagen
• oral and written consent by their parents

Exclusion criteria

• children who can not cooperate to DEXA scanning or other procedures
• linguistic difficulties that impair communication

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Lifestyle counseling

Experimental group

Description:

Treatment protocol The Children's Obesity Clinic Department of Paediatrics Holbaek Hospital, University of Copenhagen Denmark

Treatment:

Behavioral: Lifestyle intervention

Control

No Intervention group

Description:

Healthy age and gender matched control subjects. Recruited from school visits.