Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

The Chinese University of Hong Kong

Status and phase: Enrolling; Phase 4

Conditions: Hypertension; End Stage Kidney Disease (ESRD); Peritoneal Dialysis

Treatments: Drug: Hydrochlorothiazide 25mg once per day

Study type: Interventional

Funder types: Other

Identifiers

NCT07271420

CREC2019.580

Details and patient eligibility

About

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

Full description

This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg).

Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg)

Exclusion criteria

• Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Thiazides treatment arm

Active Comparator group

Treatment:

Drug: Hydrochlorothiazide 25mg once per day

Control arm

No Intervention group