Blood Purification Therapy With Dual-cannula in Jugular-femoral Venous

Fudan University

Status: Not yet enrolling

Conditions: Blood Purification; Vena Cava Disconnection; Dual-cannula

Treatments: Device: Hemodialysis Catheter

Study type: Interventional

Funder types: Other

Identifiers

NCT05510713

jv-fv-RRT

Details and patient eligibility

About

Acute kidney failure (AKI) is one of the most important causes of morbidity and mortality for critical ill patients. The use of blood purification treatment such as renal replacement therapy (CRRT) and plasma exchange has gradually developed into an effective treatment. However, the efficiency of blood purification may be affected by the recirculation of dual-lumen venous catheter for some special patients including patients with vena cava reflux disorder from massive occupations or ascites. For extreme cases like patients with vena cava disconnection or severe obstruction, the traditional blood purification treatment cannot work effectively. Thus, we used the dual-cannula in jugular-femoral venous blood purification therapy in the following two patients and found that it can improve the perfusion of systemic circulation and the prognosis of patients

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. patients requiring haemodilution therapy for various reasons (acute renal failure, acute liver failure, etc.)
• 2. presence of superior vena cava and/or inferior vena cava reflux disorders
• 3. age greater than 18 years

Exclusion criteria

• 1. Inability to establish suitable vascular access
• 2. Pregnant women
• 3. Not agreeing to active life support treatment
• 4. Severe active bleeding

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

the treatment-as-usual group

No Intervention group

Description:

we used the single-cannula in femoral venous blood purification therapy in the following patients with vena cava disconnection or severe obstruction

intervention group

Experimental group

Description:

we used the dual-cannula in jugular-femoral venous blood purification therapy in the following patients with vena cava disconnection or severe obstruction

Treatment:

Device: Hemodialysis Catheter