Blood Samples From Patients With Non-Small Cell Lung Cancer and From Healthy Volunteers

University of Minnesota (UMN)

Status

Completed

Conditions

Lung Cancer

Treatments

Other: Mass Spectrometry

Study type

Observational

Funder types

Other

Identifiers

NCT00897234

2008NTLS094

0809M47482 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at blood samples from patients with non-small cell lung cancer and from healthy volunteers.

Full description

OBJECTIVES:

Measure plasma cathepsin D levels in patients with non-small cell lung cancer and in healthy volunteers using mass spectometry.
Measure fatty acid synthase levels in these patients and healthy volunteers using mass spectometry.

OUTLINE: Blood samples are collected from patients and healthy volunteers to measure the levels of cathepsin D and fatty acid synthase by proteomic profiling and mass spectrometry.

Enrollment

84 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Non-Small Cell Lung Cancer Patients

Documented diagnosis of non-small cell lung cancer, any stage and any time point in the course of treatment (i.e., at diagnosis, during any treatment, and during post treatment surveillance)
Measurable disease by CT scan within the past 4 weeks

Healthy volunteer

Non-smoking, defined as < 5 packs/year history of smoking and cessation of smoking ≥ 6 months ago OR a never smoker
- Not regularly exposed (i.e., daily) to second-hand smoke

Exclusion criteria

Severe underlying lung disease (i.e., chronic obstructive pulmonary disease with FEV_1 < 1.0 L, pulmonary fibrosis, bronchiectasis, cystic fibrosis, etc.) as determined by enrolling researcher.

Written consent must be given for both subjects and controls.