ClinicalTrials.Veeva

Menu

Blue Light for Treating Eczema

Philips logo

Philips

Status

Completed

Conditions

Eczema

Treatments

Device: PSO-CT02 device

Study type

Interventional

Funder types

Industry

Identifiers

NCT02002871
EczemaCT01
CIV-13-08-011581 (Other Identifier)

Details and patient eligibility

About

Monocenter, randomized, intraindividual, open label, exploratory study comparing 4 weeks of treatment with 453nm blue light with no treatment in patients with Eczema. Patients will be screened up to 28 days before start of treatment. During the screening visit, the purpose and procedures of the study will be explained to potential patients and informed consent will be obtained. In addition, fungal superinfection of the target area will be examined using direct preparations and mycology cultures. At the baseline visit, patients with Eczema will be determined and all inclusion and exclusion criteria will be assessed. For eligible patients, two comparable treatment areas will be randomized to treatment with blue light (target area) or to serve as untreated control area. After randomization, patients will receive treatment of the target area with 3 applications per week at the investigational site for a total treatment period of 4 weeks. During those 4 weeks, safety and effectiveness assessments will be performed at weekly intervals. After end of treatment, the patients will be followed-up for another 2 weeks. In case no full resolution of adverse events occurred at the 2 week follow-up visit, a follow-up call will be performed after another 2 weeks. Treatment responses will be photo documented

Enrollment

21 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Signed and dated informed consent prior to any study-mandated procedure

  2. Good health as determined by the Investigator according to physical examination

  3. Willing and able to comply with study requirements

  4. Skin type I-IV according to Fitzpatrick

  5. Eczema, severity defined by an Eczema Area Severity Index (EASI)smaller/equal 20

  6. Comparable clinical symptomatology of both intended treatment Areas

  7. Reliable method of contraception for women of childbearing potential (i.e. low failure rate less than 1% per year; e.g. oral contraceptives, intrauterine device [IUD] or transdermal contraceptive patch) 9. Willing to abstain from excessive sun / UV exposure (e.g. sunbathe, solarium) during the course of the study

Exclusion criteria

  1. Inmates of psychiatric wards, prisons, or other state institutions
  2. Investigator or any other team member involved in the conduct of the clinical study
  3. Participation in another clinical trial within the last 30 days
  4. Pregnant and lactating women
  5. Photodermatosis and/or Photosensitivity
  6. Porphyria and/or hypersensitivity to porphyrins
  7. Congenital or acquired immunodeficiency
  8. Patients with any of the following conditions present on the study areas; Malignoma of the skin or severe actinic damage of the skin, atypical naevi or signs of hyperpigmentation, precancerosis viral (e.g. herpes or varicella) lesions of the skin, fungal and bacterial skin infections, parasitic infections and atrophic skin
  9. Patients with genetic deficiencies attached with increased sensitivity to light or increased risk to dermatologic cancer (i.e. Xeroderma pigmentosum, Cockayne Syndrome, Bloom- Syndrome)
  10. Current diagnosis of exfoliative or toxic dermatitis.
  11. Evidence of superinfection of the intended treatment areas

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

21 participants in 2 patient groups

Blue light
Experimental group
Description:
Irradiation with PSOCT02 device emitting blue light at a wavelength of 453nm
Treatment:
Device: PSO-CT02 device
Control
No Intervention group
Description:
contralateral untreated control plaque on the same patient.

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems