Blue Light Therapy for Liver Surgery

University of Pittsburgh

Status: Terminated

Conditions: Liver Injury; Inflammation; Acute Kidney Injury

Treatments: Other: Blue light

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT02915081

PRO13080427

Details and patient eligibility

About

The investigators hypothesize that subjects undergoing liver resection and who are exposed preoperatively to high illuminance blue spectrum light will exhibit reduced organ injury, specifically liver dysfunction, than subjects exposed to standard ambient white fluorescent light.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age greater than 17 years
• undergoing right or left hepatic lobectomy

Exclusion criteria

• presence of acute traumatic brain injury
• blindness
• immunosuppression or immunocompromised condition

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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6 participants in 2 patient groups

Blue light

Experimental group

Description:

Subjects will be exposed to 24 hours of bright (1700 lux) blue (peak 442 nm) spectrum light the day prior to operative intervention and for the 24 hours after the operative intervention.

Treatment:

Other: Blue light

Ambient light

No Intervention group

Description:

Subjects will be exposed preoperatively to the lighting conditions of their living environment and postoperatively to the standard, white fluorescent lighting environment of the hospital.