Body Composition Study in Critically Ill Patients-Extended to COVID-19 (COVID-MUSCLE)

University of Malaya

Status: Active, not recruiting

Conditions: Muscle Atrophy; Muscle Strength; Critical Illness; Covid19

Treatments: Other: No Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04849624

2019615-7520-3

Details and patient eligibility

About

Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.

Full description

Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 18 years old
• Admitted into the ICU due to COVID-19

Exclusion criteria

• Likely to transfer out from the ICU in 24 hours from screening
• Likely to die in the next 7 days
• Bedbound prior to hospital admission or bedbound in the hospital for >10 days

Trial design

50 participants in 2 patient groups

ICU COVID-19 patients

Description:

COVID-19 patients that are admitted into the ICU and fulfilled the eligibility criteria

Treatment:

Other: No Intervention

ICU non-COVID-19 patients

Description:

Non-COVID-19 patients that are admitted into the ICU matched with ICU COVID-19 patients that are recruited and fulfilled the eligibility criteria

Treatment:

Other: No Intervention