Body Responses to Bean Physical Form and "Beano" (BFE)

Purdue University

Status: Completed

Conditions: Appetite and Glucose Responses

Treatments: Other: blended lentils; Other: no lentils; Other: whole lentils

Study type: Interventional

Funder types: Other

Identifiers

NCT02110511

1107011010

Details and patient eligibility

About

The aim of this study is to determine the effects of bean physical form (whole versus blended) and Beano on postprandial responses. The postprandial responses the investigators will examine include blood glucose, appetite, metabolic rate, physical symptoms, and mood. To accomplish this aim the investigators will conduct a randomized, placebo-controlled trial in overweight and obese but otherwise healthy (non-diabetic) men and women

Enrollment: 14 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged 18-55 years old
• Body mass index (BMI) 18.5-40 kg/m2
• Generally healthy
• A non-smoker
• Any ethnicity
• Free of chronic diseases and not taking medications or dietary supplements known to affect energy regulation or appetite

Exclusion criteria

• Beano drug label warnings including galactosemia, severe liver or kidney disease, allergies or sensitivities to any of the ingredients in Beano
• Peri and postmenopausal women
• Pregnant or lactating women (currently and within the past 1 year)
• Currently dieting or consuming unusual or a medically prescribed diet
• Net weight loss or gain (>5 lbs) within the last six months
• Consuming 1/2c per day or more of legumes, not including peanuts
• Having taken Beano any time in the past 3 months
• Extreme problems digesting beans
• Fasting glucose >126 mg/dl
• Blood pressure >140/90 mmHg
• Moderate intensity or higher intensity exercise > 6 h/wk
• Predicted energy requirement < 2000 kcal/d or >4000 kcal/d

Trial design

14 participants in 6 patient groups, including a placebo group

alpha-gal & blended lentils

Experimental group

Description:

3 capsules of alpha-gal taken with blended lentils

Treatment:

Other: blended lentils

alpha-gal & whole lentils

Experimental group

Description:

3 calpsules of alpha-gal taken with whole lentils

Treatment:

Other: whole lentils

alpha-gal & no lentils

Experimental group

Description:

3 capsules of alpha-gal taken with no lentils control

Treatment:

Other: no lentils

Placebo & blended lentils

Placebo Comparator group

Description:

3 capsules of placebo taken with blended lentils

Treatment:

Other: blended lentils

Placebo & whole lentils

Placebo Comparator group

Description:

3 capsules of placebo taken with whole lentils

Treatment:

Other: whole lentils

Placebo & no lentils

Placebo Comparator group

Description:

3 capsules of placebo taken with no lentils control

Treatment:

Other: no lentils