Bone Density Change in Postmenopausal Rheumatoid Arthritis

Istanbul University - Cerrahpasa

Status: Completed

Conditions: Osteoporosis; Rheumatoid Arthritis (RA)

Treatments: Diagnostic Test: Bone Density Test

Study type: Observational

Funder types: Other

Identifiers

NCT07336693

IstanbulUC-BCetin-03

Details and patient eligibility

About

Rheumatoid arthritis is associated with systemic inflammation-mediated bone loss, leading to an increased risk of osteoporosis and fractures, particularly in postmenopausal patients. Although disease-modifying antirheumatic drugs may help mitigate bone loss, comparative longitudinal data on different treatment strategies remain limited. This study aimed to evaluate changes in bone mineral density over time and assess the impact of conventional synthetic and biologic DMARDs, together with anti-osteoporotic therapy, on bone health.

Enrollment: 82 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Postmenopausal women with a confirmed diagnosis of rheumatoid arthritis

Exclusion criteria

• Concomitant inflammatory rheumatic diseases other than RA
• History of malignancy
• Uncontrolled or untreated endocrine or metabolic disorders affecting bone metabolism, such as primary hyperparathyroidism, Cushing's syndrome, severe renal failure, severe hepatic failure
• Incomplete medical records or missing data

Trial design

82 participants in 1 patient group

Postmenopausal Patients with Rheumatoid Arthritis

Description:

Postmenopausal women with a confirmed diagnosis of RA were identified. Postmenopause was defined as ≥12 months of spontaneous amenorrhea or a prior bilateral oophorectomy; women receiving hormone replacement therapy who fulfilled these criteria were also considered postmenopausal.

Treatment:

Diagnostic Test: Bone Density Test