Bone Development in Adolescent Girls: Effects of Calcium and Exercise

United States Department of Health and Human Services (HHS)

Status and phase

Unknown

Phase 2

Phase 1

Conditions

Osteoporosis

Treatments

Behavioral: Weight bearing exercise

Behavioral: Calcium rich diet

Study type

Interventional

Funder types

NIH

Identifiers

NCT00063011

R01HD036601

Details and patient eligibility

About

Osteoporosis is a major public health problem. Prevention of osteoporosis depends in part on good bone development in childhood and adolescence. This study will evaluate a weight-bearing exercise program and high-calcium diet on bone development in adolescent girls.

Full description

There are currently few safe and effective methods for restoring lost bone to the osteoporotic skeleton. Therefore, prevention of osteoporosis is crucial. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone mass and will be less likely to develop osteoporosis in later years. This study will determine the effects of weight-bearing physical activity and a high-calcium diet on bone mass in adolescent girls.

Participants in this study will be randomized to one of three study arms. Girls in Arm 1 will consume their usual diets and will participate in a weight-bearing exercise program that meets 3 times per week. Girls in Arm 2 will also participate in a weight-bearing exercise program that meets 3 times per week and will be given high calcium foods to supply 1500 mg of calcium per day. Girls in Arm 3 will consume their usual diet and maintain their customary activity level. Study visits occur every 6 months; participants will be followed for 4 ½ years. Assessments will include a medical and social history and measurements of spine, hip, radius, and total body bone mineral content (BMC); calcaneal speed of sound (SOS); height; weight; and Tanner stage.

Sex

Female

Ages

9 to 10 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Tanner Stage of Development: Stage 1

Exclusion Criteria

History of lactose intolerance, milk allergy, corticosteroid or anticonvulsant therapy, familial hypercholesterolemia, mental or physical handicaps, cancer, rheumatoid arthritis, asthma, or any other significant health problem
Body mass index (BMI) >= 85th percentile for age and gender
Regularly have more than two practice sessions per week of dance, gymnastics, or organized team sports