Bone Intake Proteins and Muscle Mass Deficiency in Proximal Femur Fractures

Medical University of Warsaw

Status: Completed

Conditions: Muscle Damage; Femoral Neck Fractures; Muscle Loss; Bone Loss; Bone Resorption; Pertrochanteric Fracture

Treatments: Procedure: Blood sample test; Procedure: Surgical treatment of proximal femur fracture and blood sample test

Study type: Observational

Funder types: Other

Identifiers

NCT05804604

WarsawMU/FOPF

Details and patient eligibility

About

The aim of this clinical trial is to compare serum concentration of bone intake proteins [ sex hormone-binding globulin (SHBG), cross linked C-telopeptide of type I collagen (CTX-I)] and muscle atrophy marker [creatine kinase (CK-MB)] between patients after the fracture of proximal femur and their age corresponding counterpart without the fracture. The main question it aims to answer is:

• Is the higher concentration of bone intake proteins and muscle atrophy marker a predictive factor of proximal femur fracture?

The part of participants (Group 1) will be hospitalized at the Department of Orthopaedics and Rehabilitation and will undergo a surgical treatment (open reduction of the fracture). The rest (Group 2) will be admitted to the Department of Internal Medicine. Participants of both Groups will have the blood sample test taken, to evaluate and compare the serum concentration of SHBG, CTX-I and CK-MB proteins.

Enrollment: 40 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age over 65
• Proximal femur fracture (Group 1)

Exclusion criteria

• neoplasmatic history in the anamnesis,
• prevalent fracture
• mental illness
• immune disease affecting protein balance

Trial design

40 participants in 2 patient groups

Level of bone intake proteins and muscle atrophy marker in patients after proximal femur fracture

Description:

Open reduction of femoral neck or pertrochanteric fracture and preoperative analysis of bone intake proteins and muscle atrophy marker serum concentration

Treatment:

Procedure: Surgical treatment of proximal femur fracture and blood sample test

Level of bone intake proteins and muscle atrophy marker in patients without proximal femur fracture

Description:

Control group without a history of proximal femur fracture. Analysis of the bone intake proteins and muscle atrophy marker serum level

Treatment:

Procedure: Blood sample test