Bone Loss in Patients With Anorexia Nervosa

University Hospital Center (CHU)

Status: Unknown

Conditions: Patients With Anorexia Nervosa

Treatments: Other: hormonal parameters dosing; Other: bone modeling markers dosing; Other: para clinical parameters description; Other: clinical parameters description

Study type: Interventional

Funder types: Other

Identifiers

NCT01907464

UF 8751

Details and patient eligibility

About

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.

160 patients (age < 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Enrollment: 320 estimated patients

Sex: Female

Ages: 14 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Informed Consent
• Health Insurance regimen or benefit from an health insurance regimen
• Aged from 14 to 38 years old
• Women
• No pregnant

Specific inclusion criteria for patient:

Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

Specific inclusion criteria for controls:

• Normal menstrual cycles,
• No lifetime history of eating disorders,
• BMI between 18 and 25 kg/m²

Exclusion criteria

• use of treatments may be modify bone mass (bisphosphonates,...)
• Disease or treatment may be induce osteoporosis
• In exclusion period in relation with another study
• Law protected subject

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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320 participants in 2 patient groups

Patients with anorexia nervosa

Experimental group

Description:

This arm is the experimental arm composed of patients

Treatment:

Other: hormonal parameters dosing

Other: clinical parameters description

Other: bone modeling markers dosing

Other: para clinical parameters description

controls subjects

Active Comparator group

Description:

This arm is composed of healthy volunteers

Treatment:

Other: hormonal parameters dosing

Other: clinical parameters description

Other: bone modeling markers dosing

Other: para clinical parameters description