Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women (ADIMOS)

University Hospital, Lille

Status

Completed

Conditions

Bone Marrow Disease

Adiposity

Fat Disorder

Fractures, Bone

Treatments

Device: dual-energy X-ray absorptiometry (DXA)

Device: Dixon Magnetic Resonance Imaging

Study type

Observational

Funder types

Other

Identifiers

NCT03219125

2017-A00472-51 (Other Identifier)

2016_44

Details and patient eligibility

About

The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.

Enrollment

203 patients

Sex

Female

Ages

50 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

post-menopausal women : 50-90 years old
Group 1 (cases) : occurence of incident major osteoporotic fracture less than 12 months
Group 2 (controls) : no history of fragility fracture

Exclusion criteria

Implants that are contraindicated for the magnetic resonance (MR) examination.
Implants that might create a health risk or other problem during an MR exam include: 1) cardiac pacemaker or implantable defibrillator, 2) catheter that has metal components that may pose a risk of a burn injury, 3) a ferromagnetic metal clip placed to prevent bleeding from an intracranial aneurysm, 4) an implanted medication pump (such as that used to deliver insulin or a pain-relieving drug), and 5) a cochlear implant.
body mass index [BMI] >38 kg/m2, weight >140 kg
Disease or current use of medications known to affect bone density, including oral glucocorticoids, treatments for osteoporosis (bisphosphonates, raloxifene, calcitonin, or PTH), hormone therapy.
Chronic kidney disease with DFG <30 ml/mn