Bone Marrow Aspirate Concentrate in Treating Mandibular Cystic Defects

Hams Hamed Abdelrahman

Status: Completed

Conditions: Mandible Cyst

Treatments: Other: Conventional enucleation only; Other: Enucleation and filling by Bone marrow aspirate

Study type: Interventional

Funder types: Other

Identifiers

NCT05748756

BM_22

Details and patient eligibility

About

Mandibular cystic defect healing is a complex process. Various methods have been developed to shorten the bone regeneration time and improve its quality. Autogenous grafting is the gold standard for filling cystic defects due to the osteogenesis property provided by the viable cells but is related to donor site morbidity. Allografts and Xenografts are used for the same purpose. However, the increased cost is their main disadvantage. Bone marrow aspirate concentrate is now used to enhance the healing and regeneration process in many areas of the body with no morbidity and low cost.

Enrollment: 16 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients suffering from mandibular cystic defect.
• Cystic defect width of 4-8 cm that requires removal under general anesthesia.

Exclusion criteria

• Medically compromised patients contradicting operation.
• Previously enucleated lesions.
• Previous surgery, tumor, infection to the pelvis affecting the anterior iliac crest.
• Infected Cysts

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

Test group

Experimental group

Treatment:

Other: Enucleation and filling by Bone marrow aspirate

Control group

Active Comparator group

Treatment:

Other: Conventional enucleation only