Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years (AMOS)

University Hospital, Lille

Status: Completed

Conditions: Osteoporosis; Anorexia Nervosa

Treatments: Device: DEXA

Study type: Observational

Funder types: Other

Identifiers

NCT02891356

2011_38

2012-A01009-34 (Other Identifier)

Details and patient eligibility

About

The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)

Enrollment: 180 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• anorexia patient defined by DSM IV diagnostic criteria

Exclusion criteria

• patient with other psychiatric disease
• patient with other a metabolic bone disease

Trial design

180 participants in 1 patient group

Anorexia patient

Description:

Dual Energy X-ray Absorptiometry (DEXA)

Treatment:

Device: DEXA