Bone Morphogenetic Protein-2 In Grade II Furcation Defects.

SVS Institute of Dental Sciences

Status: Completed

Conditions: Periodontitis

Treatments: Procedure: PLATELET RICH FIBRIN in grade II furcation; Drug: RhBMP-2 absorbable sponge in grade II furcation

Study type: Interventional

Funder types: Other

Identifiers

NCT04372420

SVSIDS/PERIO/3/2017

Details and patient eligibility

About

The present study evaluated clinically and radiographically the regenerative potential of rhBMP-2 in absorbable sponge and PRF in Grade II furcation.

Full description

44 subjects were enrolled in the study. PPD, CAL, plaque index and gingival index were recorded and the evaluation of bone fill was performed after 6 months by using ImageJ® software. After 6 months, the bone fill obtained with rhBMP-2 was higher when compared to PRF. From this trial conducted over a period of 6 months, the unique properties associated with rhBMP-2 in absorbable sponge makes it a potential agent to be used as a graft material for Grade II furcation defects.

Enrollment: 44 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemically healthy male and female patients of age group 20-55 yrs
• grade II furcation involvement and probing pocket depth of ≥5mm

Exclusion criteria

• Medically compromised patients
• subjects who underwent radiotherapy or chemotherapy in the past 12 months
• patients having uncontrolled periodontal disease and
• subjects smoking ≥10 cigarettes per day were excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 2 patient groups, including a placebo group

RhBMP-2

Active Comparator group

Description:

RhBMP-2 belongs to TGF-β super family with osteoinductive property which is capable of promoting bone formation

Treatment:

Drug: RhBMP-2 absorbable sponge in grade II furcation

PLATELET RICH FIBRIN

Placebo Comparator group

Description:

Platelet rich fibrin(PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions

Treatment:

Procedure: PLATELET RICH FIBRIN in grade II furcation