Bone Status and Insulin Resistance in Hirsutism

Odense University Hospital

Status: Completed

Conditions: Hirsutism

Study type: Observational

Funder types: Other

Identifiers

NCT00143052

003

Details and patient eligibility

About

The purpose of this study is to investigate how the bones of hirsute women are different from bones of healthy women. The change in hormone content in the blood will also be investigated. The study can be used to evaluate whether it will be relevant to bone scan all newly referred hirsute women.

Hirsute women are often over-weight and often have an increased amount of the male sex hormone in their blood. Their blood tests often show changes reminding of the ones seen in diabetic patients.

All hirsute women referred to the department will undergo an investigation revealing the reason for the increased hair growth. The investigation includes clinical investigation (height, weight and degree of hair growth), blood tests (for hormone status and bone status analysis) and bone scanning of the abdomen (body composition).

The trial includes a group of 50 strongly hairy women and a control group of 50 healthy women with normal hair growth. They are matched by body weight, since weight has great importance for the bone mineral content and thereby for osteoporosis in the long run.

Enrollment: 50 patients

Sex: Female

Ages: 20 to 46 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Hirsute subjects:

• Belonging to group 1 or 2.
• Age: 20-46
• Hirsute score: >7
• Written informed consent

Control group:

• Age: 20-46
• Hirsute score: 0 (without razing)
• Regular menses
• Written informed consent

Exclusion criteria

• Previous cosmetic treatment for hirsutism.
• Use of contraceptive pill (within the past 6 months)
• Systemic steroid treatment > 6 weeks (ever)
• Age above 46 years/post menopause (increased FSH)
• Recognized diabetes mellitus or other endocrine disease
• Eating disorder
• Serious, treatment demanding disease