Bone Strength After Spinal Cord Injury

Swiss Paraplegic Research, Nottwil

Status: Completed

Conditions: Spinal Cord Injury

Treatments: Radiation: DXA; Radiation: pQCT

Study type: Observational

Funder types: NETWORK

Identifiers

NCT01853488

2010-13

Details and patient eligibility

About

Background:

After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk.

Aims:

To compare the two measurement methods DEXA and pQCT concerning optimal diagnostics and assessment of fracture risk in subjects with spinal cord injury.

Subjects:

250 women and 250 men (age≥18, any AIS-classification) with an acute or chronic spinal cord injury will be recruited for this study. For a reference group, 500 able-bodied persons will be measured analogously.

Methods:

Using DEXA-Osteodensitometry, bone parameters of the lumbar vertebral column, proximal femur, distal radius, distal tibia and knee area will be assessed. Additionally, geometric bone parameters of the tibia will be measured by using pQCT. All measurements will be done unilaterally. For the assessment of potential risk factors for reduced bone stiffness after spinal cord injury a questionnaire will be used.

Enrollment: 273 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Spinal Cord Injury
• mobilized patients
• written informed consent

Exclusion criteria

• current fracture
• limited mobility
• contractures of the lower limbs
• decubitus ulcer
• pregnancy

Trial design

273 participants in 2 patient groups

Spinal Cord Injury

Description:

Persons with spinal cord injury Osteodensitometry DXA pQCT

Treatment:

Radiation: DXA

Radiation: pQCT

Reference

Description:

Reference population (able-bodied) Osteodensitometry DXA pQCT

Treatment:

Radiation: DXA

Radiation: pQCT