Bone Structure in Patients with Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography

Odense University Hospital

Status: Completed

Conditions: Adult Onset Growth Hormone Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT02218710

S-20120156

Details and patient eligibility

About

The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone deficiency.

Enrollment: 45 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women diagnosed with Adult onset Growth Hormone Deficiency
• Age between 18-80
• Informed consent

Exclusion criteria

• Competing bone disease (e.g.. Mb. Paget, myelomatosis, osteogenesis imperfecta, osteoporosis, primary hyperparathyroidism)
• Ongoing medical treatment affecting bone metabolism (eg. osteoporosis medications)
• Ongoing pregnancy or breast feeding

Trial design

45 participants in 2 patient groups

Growth hormone deficiency (GHD)

Description:

Pituitary patients with GHD

healthy controls

Description:

Sex and age-matched healthy controls