Booster Dose of HCG for Unruptured Follicle in Non IVF/ICSI Cycles

Tanta University

Status and phase: Completed; Phase 4

Conditions: LUF - Luteinised Unruptured Follicle Syndrome

Treatments: Drug: hCG; Drug: Saline Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT03580031

Ayman HCG

Details and patient eligibility

About

This study will be conducted to assess the effect of booster dose of hCG on the unruptured follicles in non IVF/ICSI cycles.

Full description

In this study enrolled patients (n=160) who underwent controlled ovarian stimulation and timed intercourse with unruptured mature graffian follicle 48 hours after IM 10,000 IU HCG dose. Patients were allocated randomly into intervention group and control group. In the intervention group another booster dose (10,000 IU of hCG) was given IM while in the control group 2 ml normal saline was given IM leaving follicles for spontaneous rupture

Enrollment: 110 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ordinary stimulated cycles
• IUI stimulated cycles
• Unruptured follicle after 10000 IU IM HCG triggering

Exclusion criteria

• IVF/ICSI cycles

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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110 participants in 2 patient groups, including a placebo group

Study group

Experimental group

Description:

HCG IM 10,000 IU Im 48 hours after first triggering dose

Treatment:

Drug: hCG

Control group

Placebo Comparator group

Description:

Saline 2m Injection im 48 hours after the first triggering dose

Treatment:

Drug: Saline Solution