Borderline of CME/D3 Dissection for Local Advanced Right-sided Colon Cancer (BLARCC)

Haixing Ju, MD

Status and phase

Active, not recruiting

Phase 3

Conditions

Colon Cancer

Treatments

Procedure: SMA lymph node dissection

Procedure: SMV lymph node dissection

Study type

Interventional

Funder types

Other

Identifiers

NCT06709144

2024IITZA001 (Other Identifier)

IRB-2024-935（IIT）

Details and patient eligibility

About

The study was conducted on patients with advanced right-sided colon cancer, and the clinical pathological and prognostic data of the patients were compared between the two groups of patients who were randomly divided into those undergoing SMV and SMA left resection, with the aim of resolving the controversy over the left resection boundary of CME/D3 lymph node dissection through this study, and to clarify whether SMA left resection is superior to SMV left resection.

Enrollment

896 estimated patients

Sex

All

Ages

18 to 78 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

right side colon cancer(The primary lesion is located in the ileocecal region, ascending colon, hepatic flexure of colon, or proximal transverse colon)
T3-4 and/or N1-2M0
Colonoscopy and pathological biopsy confirmed colon adenocarcinoma

Exclusion criteria

T1-2N0M0
Cannot undergo curative resection
Simultaneous multiple primary colorectal cancer or other diseases requiring segmental resection
Distant metastasis
Tumor invades surrounding organs, requiring joint organ resection
Emergency surgery is required for complications such as intestinal obstruction, perforation, and bleeding
Patients who have received neoadjuvant therapy before surgery
Pregnant or lactating women
Patients who are not suitable or unable to tolerate surgery