Bortezomib in Treating Patients With Advanced or Metastatic Transitional Cell Cancer of the Bladder, Renal Pelvis, or Ureter

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University Health Network, Toronto

Status and phase

Phase 2


Transitional Cell Cancer of the Renal Pelvis and Ureter
Bladder Cancer


Drug: bortezomib

Study type


Funder types



CDR0000315537 (Registry Identifier)

Details and patient eligibility


RATIONALE: Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. PURPOSE: This phase II trial is studying how well bortezomib works in treating patients with advanced or metastatic transitional cell cancer of the bladder, renal pelvis, or ureter.

Full description

OBJECTIVES: Determine the response rate and duration of response in patients with advanced or metastatic transitional cell cancer of the bladder, renal pelvis, or ureter when treated with bortezomib. Determine the 1-year, median, and overall survival rate of patients treated with this drug. Determine the stable disease rate and duration and time to progression in patients treated with this drug. Determine the toxicity of this drug in these patients. Correlate baseline and post-treatment levels of NF-kappaB and HIF-1 alpha in tumor biopsies with clinical outcome in patients treated with this drug. OUTLINE: This is a nonrandomized, open-label, multicenter study. Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients in complete remission (CR) may receive up to 2 courses after confirmation of CR. Patients are followed within 3 weeks and then every 3 months thereafter. PROJECTED ACCRUAL: A total of 20-35 patients will be accrued for this study within approximately 6.6-17.5 months.




18+ years old


No Healthy Volunteers

Inclusion and exclusion criteria


Histologically or cytologically confirmed transitional cell cancer of the urothelium, including the bladder, renal pelvis, or ureter

Advanced or metastatic disease

At least 1 unidimensionally measurable lesion

At least 20 mm by conventional techniques OR at least 10 mm by spiral CT scan

The following are not considered measurable disease:

  • Bone lesions
  • Leptomeningeal disease
  • Ascites
  • Pleural/pericardial effusion
  • Inflammatory breast disease
  • Lymphangitis cutis/pulmonis
  • Abdominal masses that are not confirmed and followed by imaging techniques
  • Cystic lesions
  • No known brain metastases



18 and over

Performance status

  • ECOG 0-1 OR
  • Karnofsky 80-100%

Life expectancy

More than 3 months


  • WBC at least 3,000/mm^3
  • Absolute neutrophil count at least 1,500/mm^3
  • Platelet count at least 100,000/mm^3


  • Bilirubin no greater than 1.25 times upper limit of normal (ULN)
  • AST/ALT no greater than 3 times ULN (less than 5 times ULN if liver metastases are present)


  • Creatinine no greater than 1.5 times ULN OR
  • Creatinine clearance at least 45 mL/min


  • No symptomatic congestive heart failure
  • No unstable angina pectoris
  • No cardiac arrhythmia


  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • Able and willing to undergo biopsy of tumor lesions
  • No other primary cancer requiring treatment within the past 3 years except curatively treated nonmelanoma skin cancer or carcinoma in situ of the cervix
  • No grade 1 or greater peripheral neuropathy
  • No ongoing or active infection
  • No other concurrent uncontrolled illness
  • No psychiatric illness or social situation that would preclude study compliance


Biologic therapy

Not specified


No more than 2 prior chemotherapy regimen for metastatic disease

  • Prior neoadjuvant or adjuvant therapy allowed provided it was completed more than 12 months prior to study entry
  • Patients who relapse within 12 months after completion of neoadjuvant or adjuvant therapy are allowed provided they did not receive chemotherapy for recurrent disease
  • More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered
  • Prior chemotherapy as a radiosensitizer is allowed* NOTE: *May be administered concurrently with radiotherapy; may be in addition to a single line of therapy for locally advanced or metastatic disease

Endocrine therapy

Not specified


  • See Chemotherapy
  • More than 4 weeks since prior myelotoxic radiotherapy (more than 3,000 cGy to fields including substantial bone marrow) and recovered
  • No concurrent radiotherapy


At least 4 weeks since prior surgery for cancer of the urothelium (except nephrostomy tubes and ureteral stents)


  • At least 4 weeks since any prior therapy and recovered
  • No other concurrent investigational or commercial agents or therapies intended to treat the malignancy
  • No concurrent combination antiretroviral therapy for HIV-positive patients

Trial contacts and locations



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