Botox and Suction-Curettage for Treatment of Excessive Underarm Sweating (Axillary Hyperhidrosis)

Northwestern University

Status

Completed

Conditions

Axillary Hyperhidrosis

Treatments

Device: Suction-Curettage

Drug: Botulinum Toxin Type A

Study type

Interventional

Funder types

Other

Identifiers

NCT01274611

STU40780

Details and patient eligibility

About

The purpose of this study is to compare the effectiveness of two methods in the treatment of excessive underarm sweating (axillary hyperhidrosis): suction-curettage and Botox injections. Suction-curettage is a method in which the doctor will insert a suction tool into two small incisions in order to suction out the sweat-producing glands. It is similar to liposuction, but instead of suctioning out fat, the doctor suctions out the layer of the deep skin where the sweat glands are located. This method has been shown in some studies to effectively reduce underarm sweating for months at a time. Botox is a Food and Drug Administration (FDA) approved drug that in small doses, paralyses muscles. It is most commonly and famously used in the treatment of facial wrinkles. However, it has also been approved to treat excessive sweating. When injected in areas that sweat excessively, sweating can be significantly reduced in that area for months at a time. This study is a pilot study designed to determine feasibility of these procedures.

Enrollment

20 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ages 18 to 65
BMI 18.5 - 29.99
Diagnosis of bilateral axillary hyperhidrosis refractory to previous topical therapies
Subject is in good health
Subject has the willingness and ability to understand and provide informed consent

Exclusion criteria

Under age 18 or over age 65
Pregnancy or lactating
BMI ≥ 30 or ≤18.4
Subjects who have undergone axillary suction/curettage any time in the past
Subjects who have undergone axillary BT-A injections in the past year
Subjects currently taking blood thinners or who have had chemotherapy or radiation within the last 6 months
Subjects with a history of a bleeding disorder
Subjects with an open, non-healing sore or infection near site of procedure
Subjects with allergies to iodine, starch powder, albumin, or any botulinum toxin product