Botulinum Toxin and Mesotherapy on Enhancement of Facial Scarring

Hams Hamed Abdelrahman

Status: Completed

Conditions: Facial Scars

Treatments: Other: Botulinum Toxin Type A; Other: Mesotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT06562023

0926-5/2024

Details and patient eligibility

About

Most of the body's tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. The scars widen when the overlying musculature pulls apart suture lines. Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis. Also, mesotherapy is the non-invasive transdermal injection which can aid the skin to increase collagen and elastin production. Thus, both techniques are eligible for enhancement of facial scars.

Enrollment: 33 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient suffering from vertical or oblique forehead lacerations caused by trauma.
• Recent and fresh wounds.
• Atrophic scar (linear scar).

Exclusion criteria

• Infected wound.
• Patient on chemotherapy treatment and history of malignancy.
• Patients suffering from burns on the forehead or complicated lacerations.
• Allergy to drugs used in this study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

33 participants in 3 patient groups

BTA injection

Experimental group

Treatment:

Other: Botulinum Toxin Type A

Mesotherapy

Experimental group

Treatment:

Other: Mesotherapy

Control

No Intervention group