Botulinum Toxin Injection in the Treatment of Open Abdomen

University of Oulu

Status: Enrolling

Conditions: Open Abdomen; Botulinum Toxin Injection

Treatments: Drug: Botulinum Toxins

Study type: Observational

Funder types: Other

Identifiers

NCT04283916

7/2020

Details and patient eligibility

About

Botulinum toxin has been widely approved and utilized in the treatment of complex abdominal wall hernias. Botulinum toxin has been only randomly studied in the treatment of open abdomen.

Full description

30 consecutive patients who have open abdomen for any indication, will have 300 IU botulinum toxin injected in three spots in either sides of the abdomen within 72 hours of the start of open abdomen. The hypothesis is botulinum toxin relaxes abdominal wall musculature to ensure better and faster closure of the open abdomen.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Open abdomen

Exclusion criteria

• Previous incisional hernia in midline
• Patient is not in active treatment

Trial design

30 participants in 1 patient group

Botox injection

Description:

30 consecutive patients will have 300 IU of botulinum toxin injected to six spots in abdominal wall to gain abdominal wall musculature relaxation.

Treatment:

Drug: Botulinum Toxins