Botulinum Toxin Injection to Prevent VT Storm

Meshalkin Research Institute of Pathology of Circulation

Status and phase: Unknown; Phase 1

Conditions: VT Storm

Treatments: Drug: BT injection

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT02003027

BT_VT Storm

Details and patient eligibility

About

The aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing episodes of VT Storm.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3 or more episodes of ventricular tachycardia within 24 hours

Exclusion criteria

• Failure to provide informed consent.
• Non-cardiac illness with a life expectancy of less than 3 year
• Non-cardiac illness imposing substantial operative mortality
• Current participation in another clinical trial in which a patient is taking an investigational drug or receiving an investigational medical device

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

---

15 participants in 1 patient group

BT injection

Experimental group

Treatment:

Drug: BT injection